BACKGROUND: 

Nonsexually acquired genital ulcers have been described among girls who are prepubertal after various viral illnesses due to mucosal inflammation from an immunologic response. Until recently, nonsexually acquired genital ulcers have only been associated with viral infections.

CASE: 

We present a case of an adolescent girl developing nonsexually acquired genital ulcers after both her first and second coronavirus disease 2019 (COVID-19) vaccine doses. Her course followed an expected timeline for severity and resolution of ulcers.

CONCLUSIONS: 

Aphthous ulcers may arise from inflammatory effects of COVID-19 vaccination. Clinical monitoring after COVID-19 vaccination from all formulations should include assessment for nonsexually acquired genital ulcers if vaginal pain is reported.

中文翻译：

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2019 年冠状病毒病 (COVID-19) 疫苗接种后青少年的外阴阿弗他溃疡

背景： 

由于免疫反应引起的粘膜炎症，在各种病毒性疾病后青春期前的女孩中已经描述了非性获得性生殖器溃疡。直到最近，非性获得性生殖器溃疡只与病毒感染有关。

案件： 

我们介绍了一个青春期女孩在第一次和第二次 2019 年冠状病毒病 (COVID-19) 疫苗接种后出现非性获得性生殖器溃疡的病例。她的疗程遵循预期的溃疡严重程度和消退时间表。

结论： 

口疮性溃疡可能由 COVID-19 疫苗接种的炎症作用引起。所有制剂接种 COVID-19 疫苗后的临床监测应包括评估非性获得性生殖器溃疡（如果报告有阴道疼痛）。