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Metal-Free [5 + 1] Cycloaddition–Aromatization of Benzotriazoles and Sulfur Ylides to Construct 1,2,4-Benzotriazines
Organic Letters ( IF 5.2 ) Pub Date : 2022-08-05 , DOI: 10.1021/acs.orglett.2c02064
Xinyuan Wang 1 , Jinhang Yu 1 , Mengjiao Xu 1 , Hui Mao 1 , Yueyue Shan 1 , Xin Lv 1 , Liejin Zhou 1
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Reported herein is a novel [5 + 1] cycloaddition–aromatization of benzotriazoles and sulfur ylides to efficiently construct 1,2,4-benzotriazine derivates with good yield. This new protocol does not employ any transition metal reagent and enables the cycloaddition by cleavage of the N–N single bond. The use of inexpensive and readily available starting materials, a broad substrate scope, mild reaction conditions, metal-free, and versatile functionalization of the 1,2,4-benzotriazines make this strategy more attractive.

中文翻译:

苯并三唑和硫叶立德的无金属 [5 + 1] 环加成-芳构化构建 1,2,4-苯并三嗪

本文报道了一种新的苯并三唑和硫叶立德的 [5 + 1] 环加成 - 芳构化,可有效构建 1,2,4-苯并三嗪衍生物,收率良好。该新协议不使用任何过渡金属试剂,并通过 N-N 单键的裂解实现环加成。使用廉价且容易获得的起始材料、广泛的底物范围、温和的反应条件、无金属和 1,2,4-苯并三嗪的多功能功能化使该策略更具吸引力。
更新日期:2022-08-05
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