Meiosis, at the transition between diploid and haploid life cycle phases, is accompanied by reprograming of cell division machinery and followed by a transition back to mitosis. We show that, in Arabidopsis , this transition is driven by inhibition of translation, achieved by a mechanism that involves processing bodies (P-bodies). During the second meiotic division, the meiosis-specific protein THREE-DIVISION MUTANT 1 (TDM1) is incorporated into P-bodies through interaction with SUPPRESSOR WITH MORPHOGENETIC EFFECTS ON GENITALIA 7 (SMG7). TDM1 attracts eIF4F, the main translation initiation complex, temporarily sequestering it in P-bodies and inhibiting translation. The failure of tdm1 mutants to terminate meiosis can be overcome by chemical inhibition of translation. We propose that TDM1-containing P-bodies down-regulate expression of meiotic transcripts to facilitate transition of cell fates to postmeiotic gametophyte differentiation.

中文翻译：

---

拟南芥的减数分裂退出是由 P 体介导的翻译抑制驱动的

减数分裂，在二倍体和单倍体生命周期阶段之间的过渡，伴随着细胞分裂机制的重新编程，然后过渡回有丝分裂。我们表明，在拟南芥，这种转变是由翻译抑制驱动的，这是通过涉及加工体（P-体）的机制实现的。在第二次减数分裂期间，减数分裂特异性蛋白三分裂突变体 1 (TDM1) 通过与对生殖器 7 (SMG7) 具有形态发生效应的抑制因子相互作用而被整合到 P 体中。TDM1 吸引主要的翻译起始复合物 eIF4F，将其暂时隔离在 P 体中并抑制翻译。的失败tdm1终止减数分裂的突变体可以通过化学抑制翻译来克服。我们建议含有 TDM1 的 P 体下调减数分裂转录物的表达，以促进细胞命运向减数分裂后配子体分化的转变。