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Are blood cytokines reliable biomarkers of allergic disease diagnosis and treatment responses?
Journal of Allergy and Clinical Immunology ( IF 14.2 ) Pub Date : 2022-08-04 , DOI: 10.1016/j.jaci.2022.06.008
Susanne Radonjic-Hoesli 1 , Nikolay Pavlov 2 , Hans-Uwe Simon 3 , Dagmar Simon 1
Affiliation  

With the development of targeted therapies for allergic diseases, the need for biomarkers supporting disease diagnosis and management has increased. Recent research has elucidated the pattern of cytokines and their distinct roles in the pathogenesis of allergic diseases. This means that cytokines should be considered as biomarkers. In this review article, we summarize published findings and critically discuss the use of cytokine measurements in association with disease diagnosis and management. Among the variety of suggested cytokines, thymus and activation-regulated chemokine (TARC) stands out and can indeed serve as a biomarker of atopic dermatitis. Both biologic characteristics and technical issues determine the reliability and limit the use of blood cytokines as biomarkers.



中文翻译:

血液细胞因子是过敏性疾病诊断和治疗反应的可靠生物标志物吗?

随着针对过敏性疾病的靶向疗法的发展,对支持疾病诊断和管理的生物标志物的需求增加了。最近的研究阐明了细胞因子的模式及其在过敏性疾病发病机制中的独特作用。这意味着细胞因子应被视为生物标志物。在这篇评论文章中,我们总结了已发表的研究结果,并批判性地讨论了细胞因子测量与疾病诊断和管理相关的使用。在各种建议的细胞因子中,胸腺和活化调节趋化因子 (TARC) 脱颖而出,确实可以作为特应性皮炎的生物标志物。生物学特性和技术问题都决定了血液细胞因子作为生物标志物的可靠性并限制了其使用。

更新日期:2022-08-05
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