In this issue of Cell Stem Cell, Victor et al. reveal that human microglia harboring the Alzheimer’s disease risk allele APOE4 have altered lipid metabolism and cellular activation. This dampens neuronal network activity, underscoring the importance of these brain-resident immune cells and highlighting a novel pathway for therapeutic intervention.

中文翻译：

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邻里关系：APOE4 小胶质细胞中脂质代谢的改变导致神经元出现问题

在本期Cell Stem Cell中，Victor 等人。揭示携带阿尔茨海默病风险等位基因 APOE4 的人类小胶质细胞改变了脂质代谢和细胞活化。这抑制了神经元网络活动，强调了这些大脑驻留免疫细胞的重要性，并突出了治疗干预的新途径。