Psoriatic arthritis (PsA) is an inflammatory musculoskeletal disease with a chronic, progressive course. Various aspects of PsA, including its clinical features, disease course and response to treatment, are influenced by sociodemographic characteristics of the patient. This includes patient sex, the biological attributes associated with being male or female, and gender, a sociocultural construct that comprises attitudes, traits and behaviours associated with being a man or a woman. An understanding of sex- and gender-related differences in PsA, as well as their underlying mechanisms, is therefore important for individualized care. In this narrative review, the influence of sex and gender on PsA manifestation and course, patient function and quality of life, and their association with comorbidities are described. Sex- and gender-related disparities in response to advanced therapies and their potential underlying mechanisms are delineated. Differences in pathophysiological mechanisms between male and female patients including genetics, immune and hormonal mechanisms are discussed. Finally, fertility and pregnancy outcomes in PsA are outlined. By adopting sex and gender lenses, this review is aimed at highlighting key differences between male and female patients with PsA and uncovering mechanisms underlying these differences, ultimately promoting individualized care of men and women with PsA and informing future research in this area.

银屑病关节炎 (PsA) 是一种具有慢性进行性病程的炎症性肌肉骨骼疾病。PsA 的各个方面，包括其临床特征、病程和对治疗的反应，都受到患者社会人口学特征的影响。这包括患者性别，与男性或女性相关的生物学属性，以及性别，一种社会文化结构，包括与男性或女性相关的态度、特征和行为。因此，了解 PsA 中性别和性别相关的差异及其潜在机制对于个性化护理非常重要。在这篇叙述性综述中，描述了性别和性别对 PsA 表现和病程、患者功能和生活质量的影响，以及它们与合并症的关系。描述了响应先进疗法的性别和性别相关差异及其潜在的潜在机制。讨论了男性和女性患者的病理生理机制差异，包括遗传、免疫和激素机制。最后，概述了 PsA 的生育力和妊娠结局。通过采用性别和性别视角，本综述旨在突出 PsA 男性和女性患者之间的主要差异，并揭示这些差异背后的机制，最终促进对 PsA 男性和女性的个体化护理，并为该领域的未来研究提供信息。讨论了免疫和激素机制。最后，概述了 PsA 的生育力和妊娠结局。通过采用性别和性别视角，本综述旨在突出 PsA 男性和女性患者之间的主要差异，并揭示这些差异背后的机制，最终促进对 PsA 男性和女性的个体化护理，并为该领域的未来研究提供信息。讨论了免疫和激素机制。最后，概述了 PsA 的生育力和妊娠结局。通过采用性别和性别视角，本综述旨在突出 PsA 男性和女性患者之间的主要差异，并揭示这些差异背后的机制，最终促进对 PsA 男性和女性的个体化护理，并为该领域的未来研究提供信息。