AACR Project GENIE: 100,000 Cases and Beyond.,Cancer Discovery

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AACR Project GENIE: 100,000 Cases and Beyond.
Cancer Discovery ( IF 28.2 ) Pub Date : 2022-09-02 , DOI: 10.1158/2159-8290.cd-21-1547
Trevor J Pugh _{1,

2,

3} , Jonathan L Bell ₄ , Jeff P Bruce ₁ , Gary J Doherty _{5,

6} , Matthew Galvin _{7,

8} , Michelle F Green ₄ , Haley Hunter-Zinck ₉ , Priti Kumari ₁₀ , Michele L Lenoue-Newton _{11,

12} , Marilyn M Li _{13,

14} , James Lindsay ₁₀ , Tali Mazor ₁₀ , Andrea Ovalle ₁₀ , Stephen-John Sammut _{5,

6} , Nikolaus Schultz ₁₅ , Thomas V Yu ₉ , Shawn M Sweeney ₁₆ , Brady Bernard _{7,

8} ,

Affiliation

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
University of Toronto, Toronto, Ontario, Canada.
Duke University Medical Center, Durham, North Carolina.
Cancer Research United Kingdom (CRUK) Cambridge Centre, Cambridge, United Kingdom.
Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Earle A. Chiles Research Institute, Portland, Oregon.
Providence Cancer Institute, Portland, Oregon.
Sage Bionetworks, Seattle, Washington.
Dana-Farber Cancer Institute, Boston, Massachusetts.
Vanderbilt University Medical Center, Nashville, Tennessee.
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
Memorial Sloan Kettering Cancer Center, New York, New York.
American Association for Cancer Research, Philadelphia, Pennsylvania.

The American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) is an international pan-cancer registry with the goal to inform cancer research and clinical care worldwide. Founded in late 2015, the milestone GENIE 9.1-public release contains data from >110,000 tumors from >100,000 people treated at 19 cancer centers from the United States, Canada, the United Kingdom, France, the Netherlands, and Spain. Here, we demonstrate the use of these real-world data, harmonized through a centralized data resource, to accurately predict enrollment on genome-guided trials, discover driver alterations in rare tumors, and identify cancer types without actionable mutations that could benefit from comprehensive genomic analysis. The extensible data infrastructure and governance framework support additional deep patient phenotyping through biopharmaceutical collaborations and expansion to include new data types such as cell-free DNA sequencing. AACR Project GENIE continues to serve a global precision medicine knowledge base of increasing impact to inform clinical decision-making and bring together cancer researchers internationally. SIGNIFICANCE AACR Project GENIE has now accrued data from >110,000 tumors, placing it among the largest repository of publicly available, clinically annotated genomic data in the world. GENIE has emerged as a powerful resource to evaluate genome-guided clinical trial design, uncover drivers of cancer subtypes, and inform real-world use of genomic data. This article is highlighted in the In This Issue feature, p. 2007.

更新日期：2022-07-12

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