We investigated differences in haemodynamic forces between carotid arteries that underwent primary closure (PC) or patch angioplasty (PA) using computational fluid dynamics (CFD). A total of 30 subjects were enrolled in this study, consisting of 10 subjects who underwent PC, 10 who underwent PA and 10 healthy subjects. Three-dimensional models of carotid arteries were reconstructed using patient-specific computed tomography angiography images. The conventional Navier-Stokes, continuity equation and constitutive stress-strain law with a stabilized Petrov-Galerkin scheme were solved with Newtonian and incompressible assumptions. The boundary conditions employed patient-specific velocity profiles as the inflow and lumped parameters of the three-element Windkessel model as the outflow with a rigid wall assumption. Thus, the CFD results exhibited good agreement with measurements from the subjects (r = .78). The carotid arteries of the PC group were exposed to abnormal haemodynamic forces related to building atherosclerosis in a smaller (p .05) to healthy arteries. The morphological characteristics of the carotid artery were significantly associated with the area exposed to abnormal haemodynamic forces. We identified that abnormal haemodynamic forces could be avoided by selecting appropriate surgical techniques that produce less bifurcation expansion.

我们使用计算流体动力学 (CFD) 研究了接受初级闭合 (PC) 或补片血管成形术 (PA) 的颈动脉之间血流动力学力的差异。本研究共招募了30名受试者，其中10名接受PC，10名接受PA和10名健康受试者。使用患者特定的计算机断层扫描血管造影图像重建颈动脉的三维模型。传统的 Navier-Stokes、连续性方程和具有稳定 Petrov-Galerkin 方案的本构应力-应变定律通过牛顿和不可压缩假设求解。边界条件采用患者特定的速度剖面作为三元 Windkessel 模型的流入参数，并采用刚性壁假设作为流出参数。因此，CFD 结果与受试者的测量结果表现出良好的一致性 (r = .78)。PC 组的颈动脉暴露于异常的血流动力学力，这与在健康动脉的较小 (p .05) 中形成动脉粥样硬化有关。颈动脉的形态特征与暴露于异常血流动力学力的区域显着相关。我们发现，可以通过选择产生较少分叉扩张的适当手术技术来避免异常的血流动力学。颈动脉的形态特征与暴露于异常血流动力学力的区域显着相关。我们发现，可以通过选择产生较少分叉扩张的适当手术技术来避免异常的血流动力学。颈动脉的形态特征与暴露于异常血流动力学力的区域显着相关。我们发现，可以通过选择产生较少分叉扩张的适当手术技术来避免异常的血流动力学。