We developed a nonequilibrium model to study chromosome structural reorganizations within a simplified cell developmental system. From the chromosome structural perspective, we predicted that the neural progenitor cell is on the neural developmental path and very close to the transdifferentiation path from the fibroblast to the neuron cell. We identified an early bifurcation of stem cell differentiation processes and the cell-of-origin-specific reprogramming pathways. Our theoretical results are in good agreement with available experimental evidence, promoting future applications of our approach.

中文翻译：

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在分化、重编程和转分化过程中量化染色体结构重组

我们开发了一个非平衡模型来研究简化细胞发育系统中的染色体结构重组。从染色体结构的角度，我们预测神经祖细胞处于神经发育路径上，并且非常接近从成纤维细胞到神经元细胞的转分化路径。我们确定了干细胞分化过程和细胞源特异性重编程途径的早期分叉。我们的理论结果与现有的实验证据非常吻合，促进了我们方法的未来应用。