We report here a Rh(III) catalyzed regio- and stereoselective synthesis of alkynylated and bis-isocoumarin from 1,3-dialkyne. Exclusive one-pot formation of 3,3-bis-isocoumarin isomers has been achieved by eliminating several other possibilities. This is the first example of transition metal catalyzed synthesis of alkynylated and bis-isocoumarin scaffolds. The protocol is compatible with a wide range of functional groups affording good to excellent yields. Several mechanistic investigations, including deuterium labeling experiments and kinetic isotope effect studies, have been carried out.

中文翻译：

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铑催化选择性 C(sp2)-H 活化/环化叔丁基苯甲酰氧基氨基甲酸酯与 1,3-二炔：一步获得炔基化异香豆素和双异香豆素

我们在此报告从 1,3-二炔烃催化的炔基化和双异香豆素的区域选择性和立体选择性合成。通过消除其他几种可能性，已经实现了 3,3-双-异香豆素异构体的独家一锅法形成。这是过渡金属催化合成炔基化和双异香豆素支架的第一个例子。该协议与广泛的功能组兼容，可提供良好的产量。已经进行了一些机械研究，包括氘标记实验和动力学同位素效应研究。