Objective: Infantile eczema (IE), a common pediatric allergic skin disease caused by multiple inherent and external factors, is common in infants and young children, with skin lesions and itching as the main clinical manifestations. At present, its pathological mechanism has not been thoroughly clarified, but scholars believe that it is related to the joint action of various internal and external factors. This research aims to investigate the influences of bifid triple viable capsules plus cetirizine (CTZ) on gut microbiota (GMB) and immunity in children with eczema.
Methods: The complete clinical data of 162 cases of IE presented between July 2019 and July 2020 to the First Hospital of Shanxi Medical University were retrospectively analyzed. Children treated by CTZ alone were assigned to the control group (n = 81) and those by CTZ plus bifid triple viable capsules were included in the observation group (n = 81). Therapeutic efficacy, adverse reactions (ARs), disease recurrence, as well as changes in GMB, inflammatory factors (IFs) and immunoglobulins (Igs) were observed.
Results: The observation group was observed with a higher overall response rate and increased fecal Lactobacillus, Escherichia coli (E. coli) and Bifidobacterium counts after treatment versus the control group. After treatment, reduced IgG and IgM, as well as IFs, were found in both groups, with lower levels in the observation group. A lower incidence of ARs was determined in the observation group.
Conclusion: With high efficacy for the treatment of IE, bifid triple viable capsules plus CTZ can validly regulate the GMB of children, improve their immune function and clinical symptoms, and reduce the disease recurrence rate, which is worthy of clinical promotion.

Keywords: bifid triple viable capsules, cetirizine, eczema, gut microbiota, immune function


中文翻译：

---

双歧三联活菌胶囊联合西替利嗪对湿疹患儿肠道菌群和免疫功能的影响

目的：婴儿湿疹（infantile eczema，IE）是由多种内在和外在因素引起的小儿常见过敏性皮肤病，多见于婴幼儿，以皮损和瘙痒为主要临床表现。目前，其病理机制尚未完全阐明，但学者认为与各种内外因素共同作用有关。本研究旨在探讨双歧三联活胶囊加西替利嗪 (CTZ) 对湿疹儿童肠道菌群 (GMB) 和免疫力的影响。
方法：对2019年7月至2020年7月山西医科大学第一医院就诊的162例IE的完整临床资料进行回顾性分析。CTZ单独治疗的儿童被分配到对照组（n = 81），CTZ加双歧三联活胶囊治疗的儿童被分配到观察组（n = 81）。观察疗效、不良反应（ARs）、疾病复发，以及GMB、炎症因子（IFs）和免疫球蛋白（Igs）的变化。
结果：观察组观察到总体反应率较高，粪便中乳酸杆菌、大肠杆菌（E.coli）和双歧杆菌增多。与对照组相比，治疗后计数。治疗后，两组患者IgG、IgM及IFs均降低，观察组降低。在观察组中确定了较低的 AR 发生率。
结论：双歧三联活菌胶囊联合CTZ治疗IE疗效显着，可有效调节儿童GMB，改善免疫功能和临床症状，降低疾病复发率，值得临床推广。

关键词：双歧三联活菌胶囊，西替利嗪，湿疹，肠道菌群，免疫功能