This manuscript studies the impact of extruding hairpins on two-dimensional self-assembly of DNA tiles on solid surface. Hairpins are commonly used as tomographic markers in DNA nanostructures for atomic force microscopy imaging. In this study, we have discovered that hairpins play a more active role. They modulate the adsorption of the DNA tiles onto the solid surface, thus changing the tile assembly kinetics on the solid surface. Based on this discovery, we were able to promote or slow down DNA self-assembly on the surface by changing the hairpin locations on the DNA tiles. This knowledge gained will be helpful for the future design of DNA self-assembly on surface.

这份手稿研究了挤压发夹对固体表面 DNA 瓦片二维自组装的影响。发夹通常用作 DNA 纳米结构中的层析标记，用于原子力显微镜成像。在这项研究中，我们发现发夹起着更积极的作用。它们调节 DNA 瓦片在固体表面上的吸附，从而改变固体表面上的瓦片组装动力学。基于这一发现，我们能够通过改变 DNA 瓦片上的发夹位置来促进或减缓 DNA 在表面的自组装。获得的这些知识将有助于未来 DNA 在表面自组装的设计。