当前位置: X-MOL 学术BMJ › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Risk of covid-19 related deaths for SARS-CoV-2 omicron (B.1.1.529) compared with delta (B.1.617.2): retrospective cohort study
The BMJ ( IF 105.7 ) Pub Date : 2022-08-02 , DOI: 10.1136/bmj-2022-070695
Isobel L Ward 1 , Charlotte Bermingham 1 , Daniel Ayoubkhani 1 , Owen J Gethings 1 , Koen B Pouwels 2 , Thomas Yates 3, 4 , Kamlesh Khunti 3, 4 , Julia Hippisley-Cox 5 , Amitava Banerjee 6, 7 , Ann Sarah Walker 8 , Vahé Nafilyan 1
Affiliation  

Objective To assess the risk of covid-19 death after infection with omicron BA.1 compared with delta (B.1.617.2). Design Retrospective cohort study. Setting England, United Kingdom, from 1 December 2021 to 30 December 2021. Participants 1 035 149 people aged 18-100 years who tested positive for SARS-CoV-2 under the national surveillance programme and had an infection identified as omicron BA.1 or delta compatible. Main outcome measures The main outcome measure was covid-19 death as identified from death certification records. The exposure of interest was the SARS-CoV-2 variant identified from NHS Test and Trace PCR positive tests taken in the community (pillar 2) and analysed by Lighthouse laboratories. Cause specific Cox proportional hazard regression models (censoring non-covid-19 deaths) were adjusted for sex, age, vaccination status, previous infection, calendar time, ethnicity, index of multiple deprivation rank, household deprivation, university degree, keyworker status, country of birth, main language, region, disability, and comorbidities. Interactions between variant and sex, age, vaccination status, and comorbidities were also investigated. Results The risk of covid-19 death was 66% lower (95% confidence interval 54% to 75%) for omicron BA.1 compared with delta after adjusting for a wide range of potential confounders. The reduction in the risk of covid-19 death for omicron compared with delta was more pronounced in people aged 18-59 years (number of deaths: delta=46, omicron=11; hazard ratio 0.14, 95% confidence interval 0.07 to 0.27) than in those aged ≥70 years (number of deaths: delta=113, omicron=135; hazard ratio 0.44, 95% confidence interval 0.32 to 0.61, P<0.0001). No evidence of a difference in risk was found between variant and number of comorbidities. Conclusions The results support earlier studies showing a reduction in severity of infection with omicron BA.1 compared with delta in terms of hospital admission. This study extends the research to also show a reduction in the risk of covid-19 death for the omicron variant compared with the delta variant. In accordance with NHS Digital’s Information Governance requirements, the study data cannot be shared.

中文翻译:

与 delta (B.1.617.2) 相比,SARS-CoV-2 omicron (B.1.1.529) 的 covid-19 相关死亡风险:回顾性队列研究

目的 评估与 delta (B.1.617.2) 相比,omicron BA.1 感染后 covid-19 死亡的风险。设计回顾性队列研究。设定于 2021 年 12 月 1 日至 2021 年 12 月 30 日期间的英国英格兰。参与者 1 035 149 名年龄在 18 至 100 岁之间的人,他们在国家监测计划下检测出 SARS-CoV-2 呈阳性,并且感染被确定为 omicron BA.1 或三角洲兼容。主要结果指标 主要结果指标是从死亡证明记录中确定的 covid-19 死亡。感兴趣的暴露是 SARS-CoV-2 变体,该变体是从社区进行的 NHS 测试和 Trace PCR 阳性测试(支柱 2)中识别出来的,并由 Lighthouse 实验室进行了分析。针对性别、年龄、疫苗接种状况、既往感染、日历时间、种族、多重剥夺等级指数、家庭剥夺、大学学历、关键工作人员身份、出生国家、主要语言、地区、残疾和合并症。还研究了变异与性别、年龄、疫苗接种状况和合并症之间的相互作用。结果 在针对广泛的潜在混杂因素进行调整后,与 delta 相比,omicron BA.1 的 covid-19 死亡风险降低了 66%(95% 置信区间为 54% 至 75%)。omicron 与 delta 相比,covid-19 死亡风险的降低在 18-59 岁人群中更为明显(死亡人数:delta=46,omicron=11;风险比 0.14,95% 置信区间 0.07 至 0.27)高于 70 岁以上的人群(死亡人数:delta=113,omicron=135;风险比 0.44,95% 置信区间 0.32 至 0.61,P<0. 0001)。没有证据表明合并症的变体和数量之间存在风险差异。结论 结果支持早期研究表明,在入院方面,与 delta 相比,omicron BA.1 的感染严重程度有所降低。这项研究扩展了研究,还表明与 delta 变体相比,omicron 变体的 covid-19 死亡风险降低。根据 NHS Digital 的信息治理要求,研究数据不能共享。这项研究扩展了研究,还表明与 delta 变体相比,omicron 变体的 covid-19 死亡风险降低。根据 NHS Digital 的信息治理要求,研究数据不能共享。这项研究扩展了研究,还表明与 delta 变体相比,omicron 变体的 covid-19 死亡风险降低。根据 NHS Digital 的信息治理要求,研究数据不能共享。
更新日期:2022-08-02
down
wechat
bug