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Electrooxidative Dearomatization of Inactive Biphenyls to Cyclohexadienones
Organic Letters ( IF 5.2 ) Pub Date : 2022-08-01 , DOI: 10.1021/acs.orglett.2c02278
Lingling Shi 1 , Lianyou Zheng 1 , Shulin Ning 1 , Qiansong Gao 1 , Chengcheng Sun 1 , Zhuoqi Zhang 1 , Jinbao Xiang 1
Affiliation  

An efficient electrooxidative dearomatization of inactive biphenyls has been developed under mild and easy-to-operate conditions. The protocol provides a powerful tool for the rapid synthesis of cyclohexadienones in moderate to high yields with wide substrate scope and good functional group compatibility even to oxidation-sensitive motifs. This method provides an environment-friendly and direct approach for the construction of C–O bonds with high regioselectivity.

中文翻译:

无活性联苯电氧化脱芳构化为环己二烯酮

在温和且易于操作的条件下,已开发出一种有效的非活性联苯的电氧化脱芳构化方法。该协议为以中等至高产率快速合成环己二烯酮提供了强大的工具,具有广泛的底物范围和良好的官能团兼容性,甚至对氧化敏感的基序也是如此。该方法为构建具有高区域选择性的C-O键提供了一种环境友好且直接的方法。
更新日期:2022-08-01
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