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Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments
Chemical Communications ( IF 4.9 ) Pub Date : 2022-08-01 , DOI: 10.1039/d2cc03072a
Lei Gan 1 , Miriam de J Velásquez-Hernández 1 , Anita Emmerstorfer-Augustin 2 , Peter Wied 1 , Heimo Wolinski 3 , Simone Dal Zilio 4 , Marcello Solomon 1 , Weibin Liang 5 , Christian Doonan 5 , Paolo Falcaro 1
Affiliation  

Metal–organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin).

中文翻译:

用于在恶劣环境中释放生物活性分子的多层 ZIF 涂层细胞

细胞上的金属有机框架 (MOF) 涂层增强了细胞毒性环境中的活力。在这里,我们展示了模型细胞系统(酵母)上的保护性多层 MOF 生物复合材料壳如何通过壳的溶解和蛋白酶抑制剂(抗胰蛋白酶)的释放来增强暴露于富含蛋白酶的恶劣环境中的活细胞的增殖。 .
更新日期:2022-08-01
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