Objective. To explore the diagnosis of cervical intraepithelial neoplasia (CIN) and invasive cervical carcinoma (ICC) by cervical biopsy under colposcopy and analyze the factors influencing the detection. Methods. The clinical data of 134 CIN confirmed by colposcopy biopsy in our hospital from June 2018 to October 2019 and subsequent LEEP treatment were analyzed retrospectively. All patients were diagnosed pathologically after the operation. The diagnosis of CIN by cervical biopsy under colposcopy was observed. The influencing factors of CIN and ICC detected by colposcopy biopsy were analyzed by the pathological results of loop electrosurgical excision procedure (LEEP) as the gold standard. Results. After LEEP, the number of the no intraepithelial or malignant lesions (NILM) or ICC were higher than that of colposcopy biopsy, and CIN-III was lower than that of colposcopy biopsy, the differences were all statistically significant (). Among the 134 patients, the coincidence rate between colposcopy biopsy and LEEP examination results was 79.10% (106/134), and postoperative pathological findings showed that there were 13 cases (9.70%) with the pathological upgrade and 19 cases (14.18%) with pathological decrease. Multivariate logistic analysis showed that the image quality of colposcopy image, atypical blood vessels, biopsy sampling method, and visible lesion area of the cervix were the independent influencing factors for the detection of CIN and ICC by colposcopy biopsy (). Conclusion. CIN and ICC can be diagnosed by colposcopy cervical biopsy and postoperative histopathology. However, there are still some missed and misdiagnosed cervical biopsies under colposcopy, and the combined detection of the two can further ensure the diagnosis rate. The clinical registration number is E2018091.

中文翻译：

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阴道镜下宫颈活检诊断宫颈上皮内瘤变和浸润性宫颈癌及影响因素分析

客观。探讨阴道镜下宫颈活检对宫颈上皮内瘤变（CIN）和浸润性宫颈癌（ICC）的诊断，并分析影响检出的因素。方法。回顾性分析我院2018年6月至2019年10月经阴道镜活检确诊的134例CIN及后续LEEP治疗的临床资料。所有患者均在术后病理确诊。观察阴道镜下宫颈活检对CIN的诊断。以环形电切术（LEEP）的病理结果为金标准，分析阴道镜活检检出CIN和ICC的影响因素。结果. LEEP后，无上皮内或恶性病变（NILM）或ICC的数量高于阴道镜活检，CIN-III低于阴道镜活检，差异均有统计学意义。）。134例患者中，阴道镜活检与LEEP检查结果的符合率为79.10%（106/134），术后病理结果显示病理升级13例（9.70%），病理升级19例（14.18%）。病理性下降。多因素logistic分析显示，阴道镜图像质量、非典型血管、活检取样方式、宫颈可见病灶面积是阴道镜活检检出CIN和ICC的独立影响因素。）。 结论。CIN和ICC可以通过阴道镜宫颈活检和术后组织病理学诊断。但阴道镜下宫颈活检仍存在一些漏诊和误诊的情况，两者联合检测可以进一步保证确诊率。临床注册号为E2018091。