An NMR supersequence is introduced for the rapid acquisition of ¹⁵N-CEST and methyl-¹³C-CEST experiments in the same pulse sequence for applications to proteins. The high sensitivity and accuracy allows the simultaneous quantitative characterization of backbone and side-chain dynamics on the millisecond timescale ideal for routine screening for alternative protein states.

中文翻译：

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用于生物分子动力学研究的 NOAH-(15N/13C)-CEST NMR 超序列

引入了 NMR 超序列，用于在同一脉冲序列中快速采集¹⁵ N-CEST 和甲基- ¹³ C-CEST 实验，以应用于蛋白质。高灵敏度和准确性允许在毫秒时间尺度上同时定量表征主链和侧链动力学，非常适合常规筛选替代蛋白质状态。