Some chemotherapeutic agents can induce distinct mutational signatures in healthy cells in patients with cancer. The effect of such mutational signatures on spermatogenesis is not fully understood but is of great clinical importance for counselling patients diagnosed with cancer planning to start a family after treatment.

中文翻译：

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化疗对精子 DNA 的致突变作用及其对计划生育的影响

一些化疗药物可以在癌症患者的健康细胞中诱导独特的突变特征。这种突变特征对精子发生的影响尚不完全清楚，但对于咨询诊断为癌症的患者计划在治疗后组建家庭具有重要的临床意义。