This article deals with the saturated solubility and solvation behavior of 2-bromo-9-fluorenone in 10 industrial common solvents and three binary mixed solvents by means of experimental and mathematical correlations. Solubility experiments were investigated using the static equilibrium method combined with high-performance liquid chromatography (HPLC) from 278.15 to 323.15 K at atmospheric pressure. The results showed that the maximum and minimum solubility of 2-bromo-9-fluorenone was 0.0526 (mole fraction) in 1,4-dioxane at 323.15 K and 0.0002 (mole fraction) in methanol at 278.15 K, respectively, and the solubility increased with the increase in temperature in all solvents. Furthermore, the solubility data of 2-bromo-9-fluorenone was analyzed using the Apelblat model, the Buchowski–Ksiazaczak λh model in pure solvents, CNIBS/R-K model, and the Jouyban–Acree model in binary solvent mixtures. By error comparison, the Apelblat model and the CNIBS/R-K model can better predict the solubility of 2-bromo-9-fluorenone. In addition, the solvation behavior was illustrated by the KAT-LSER model in pure solvents, and the result shows that the cohesive energy density in the solution is the main factor affecting 2-bromo-9-fluorenone. Therefore, the solubility data is very important for optimizing the extraction process and recrystallizing 2-bromo-9-fluorenone to obtain a higher yield in industry production.

中文翻译：

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2-Bromo-9-芴酮在不同温度下（T = 278.15–323.15 K）在 10 种不同有机溶剂和三种二元溶剂混合物中溶解度的测定和分析

本文通过实验和数学相关性研究了2-溴-9-芴酮在10种工业常用溶剂和三种二元混合溶剂中的饱和溶解度和溶剂化行为。使用静态平衡法结合高效液相色谱 (HPLC) 在大气压下从 278.15 到 323.15 K 研究溶解度实验。结果表明，2-溴-9-芴酮在323.15 K时在1,4-二恶烷中的最大和最小溶解度分别为0.0526（摩尔分数）和在278.15 K时在甲醇中的0.0002（摩尔分数），溶解度增加随着所有溶剂中温度的升高。此外，使用 Apelblat 模型 Buchowski-Ksiazaczak λ h分析了 2-溴-9-芴酮的溶解度数据纯溶剂模型、CNIBS/RK 模型和二元溶剂混合物中的 Jouyban-Acree 模型。通过误差比较，Apelblat模型和CNIBS/RK模型可以更好地预测2-溴-9-芴酮的溶解度。此外，通过KAT-LSER模型说明了纯溶剂中的溶剂化行为，结果表明溶液中的内聚能密度是影响2-溴-9-芴酮的主要因素。因此，溶解度数据对于优化提取工艺和重结晶2-溴-9-芴酮以获得更高的工业生产收率非常重要。