ABSTRACT

Objective

Emerging research suggests that the use of serotonergic psychedelics can be associated with reductions in obsessions and compulsions. However, little research to date has attempted to understand why this may be the case. The present study aimed to extend existing research by examining reduced death anxiety and obsessive beliefs as potential mechanisms underpinning the relationship between acute psychedelic effects and reductions in obsessions and compulsions.

Methods

Participants (N = 312) who had reported having a significant psychedelic experience completed a retrospective survey that measured aspects of their experience as well as changes in death anxiety, obsessive beliefs, and obsessions and compulsions.

Results

Acute subjective effects (i.e., mystical experiences; psychological insight) significantly predicted self-reported reductions in (a) obsessive beliefs, (b) death anxiety, and (c) obsessions and compulsions following a psychedelic experience. Mediation analyses evidenced significant indirect effects of mystical experiences, but not psychological insights, on obsessions and compulsions through reduced death anxiety and obsessive beliefs.

Conclusion

These findings highlight the links between death anxiety, obsessive beliefs and obsessive-compulsive disorder symptomology, suggesting that reductions in obsessions and compulsions as a result of psychedelic use might, in part, be due to persisting effects of acute psychedelic experiences on these variables.

中文翻译：

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减少死亡焦虑和强迫信念作为迷幻药对强迫症症状学治疗效果的中介

摘要

客观的

新兴研究表明，使用血清素能迷幻药可能会减少强迫症和强迫症。然而，迄今为止，很少有研究试图理解为什么会出现这种情况。本研究旨在通过检查减少死亡焦虑和强迫信念作为支持急性迷幻效应与减少强迫症和强迫行为之间关系的潜在机制来扩展现有研究。

方法

报告有重大迷幻经历的参与者 (N = 312) 完成了一项回顾性调查，该调查衡量了他们经历的各个方面以及死亡焦虑、强迫性信念、强迫症和强迫症的变化。

结果

急性主观效应（即神秘体验；心理洞察力）显着预测了自我报告的 (a) 强迫性信念、(b) 死亡焦虑和 (c) 迷幻体验后的强迫症和强迫症的减少。调解分析证明，神秘经历而非心理洞察力通过减少死亡焦虑和强迫信念对强迫症和强迫症产生显着的间接影响。

结论

这些发现强调了死亡焦虑、强迫信念和强迫症症状学之间的联系，表明迷幻药使用导致的强迫症和强迫症减少可能部分是由于急性迷幻药经历对这些变量的持续影响。