A tertiary amine-catalyzed asymmetric [3+2] spiroannulation reaction of pyrazolone-derived Morita–Baylis–Hillman carbonates with alkynyl ketones was achieved under mild conditions. This protocol offers a facile approach to chiral spiro[cyclopentadiene-pyrazolone] scaffolds in good to high yields (up to 92%) with good degrees of enantiocontrol (up to 98% ee). In addition, scale-up reaction and transformation of the products were performed to show the synthetic utility of this protocol.

中文翻译：

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吡唑啉酮衍生的 Morita-Baylis-Hillman 碳酸盐与炔基酮的不对称 [3+2] 螺环化：容易获得螺[环戊二烯-吡唑啉酮] 支架

在温和条件下实现了吡唑啉酮衍生的 Morita-Baylis-Hillman 碳酸盐与炔基酮的叔胺催化不对称 [3+2] 螺环化反应。该协议为手性螺[环戊二烯-吡唑啉酮] 支架提供了一种简便的方法，具有良好的对映控制度（高达 98% ee）的良好至高产率（高达 92%）。此外，还对产品进行了放大反应和转化，以展示该协议的合成效用。