3-Acylindole motifs are wildly found in pharmaceuticals and biologically active alkaloids. Synthesis of this motif from aldehydes and indoles via dehydrogenative cross-coupling (CDC) reactions is the most efficient pathway. Here, we report a method for synthesis of 3-acyl indoles from aldehydes by a combination of photocatalysis and palladium catalysis. This mild, robust method is compatible with a wide array of functional groups and has a broad substrate scope. Our findings may inspire the development of new CDC reactions.

中文翻译：

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钯金属光氧化还原催化吲哚衍生物的3-酰化

3-酰基吲哚基序广泛存在于药物和生物活性生物碱中。通过脱氢交叉偶联 (CDC) 反应从醛和吲哚合成该基序是最有效的途径。在这里，我们报告了一种通过光催化和钯催化相结合的醛类合成 3-酰基吲哚的方法。这种温和、稳健的方法与广泛的官能团兼容，并且具有广泛的底物范围。我们的发现可能会激发新的 CDC 反应的发展。