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Early Changes in Striatal Activity and Motor Kinematics in a Huntington's Disease Mouse Model
Movement Disorders ( IF 8.6 ) Pub Date : 2022-07-26 , DOI: 10.1002/mds.29168
Ellen T Koch 1, 2 , Marja D Sepers 1 , Judy Cheng 1, 2 , Lynn A Raymond 1
Affiliation  

Huntington's disease is a progressive neurodegenerative disorder with no disease-modifying treatments. Patients experience motor, cognitive, and psychiatric disturbances, and the dorsal striatum is the main target of neurodegeneration. Mouse models of Huntington's disease show altered striatal synaptic signaling in vitro, but how these changes relate to behavioral deficits in vivo is unclear.

中文翻译:

亨廷顿病小鼠模型中纹状体活动和运动学的早期变化

亨廷顿氏舞蹈病是一种进行性神经退行性疾病,没有任何疾病缓解疗法。患者经历运动、认知和精神障碍,背侧纹状体是神经变性的主要目标。亨廷顿氏病小鼠模型显示体外纹状体突触信号发生改变,但这些变化与体内行为缺陷的关系尚不清楚。
更新日期:2022-07-26
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