Saccharide/lipid nanoconjugates are attractive building blocks for the construction of micro- and nanosized structures because of the roles of glycolipids in human body, courtesy of their intrinsic and functional properties. Herein, nanoconjugates based on dextran and oleic acid (Dex-OA) were synthesized via facile amide-linkage chemistry. The resultant Dex-OA micelles could self-assemble into spherical water-filled microcapsules via a water-in-oil emulsification process. By cross-linking, the microcapsules could be transferred to aqueous media, forming a stable microcapsule dispersion. According to optical and fluorescence microscopy, the microcapsules displayed a spherical morphology, and their synthesis is dependent on the concentration of Dex-OA nanoconjugates. Furthermore, the microcapsules could easily encapsulate and retain fluorescently labeled dextran. This strategy offers a robust and efficient method for the construction of microcapsules from fully natural amphiphilic building blocks with the potential for application in diverse fields such as biomedicine, protocell research, and microreactors.

中文翻译：

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多糖/脂质纳米缀合物作为高度生物相容性微胶囊的替代构件

由于糖脂在人体中的作用，由于糖脂的内在和功能特性，糖/脂质纳米缀合物是构建微米级和纳米级结构的有吸引力的构件。在此，通过简便的酰胺键化学合成了基于葡聚糖和油酸 (Dex-OA) 的纳米缀合物。所得的 Dex-OA 胶束可以通过油包水乳化过程自组装成球形充水微胶囊。通过交联，微胶囊可以转移到水性介质中，形成稳定的微胶囊分散体。根据光学和荧光显微镜，微胶囊呈球形，其合成取决于 Dex-OA 纳米偶联物的浓度。此外，微胶囊可以很容易地封装和保留荧光标记的葡聚糖。该策略为从完全天然的两亲性构件构建微胶囊提供了一种稳健而有效的方法，具有在生物医学、原始细胞研究和微反应器等不同领域应用的潜力。