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Regression of calcinosis cutis after inkless tattoo in a patient with dermatomyositis: therapeutic potential of microneedling
Osteoporosis International ( IF 4 ) Pub Date : 2022-07-26 , DOI: 10.1007/s00198-022-06501-z
Yasaman Motlaghzadeh , Laila S. Tabatabai , Eric Longo , Deborah E. Sellmeyer

Calcinosis cutis is defined as abnormal deposition of calcium salts in the skin and subcutaneous tissues. Dystrophic calcification, the most common form of calcinosis cutis, is associated with autoimmune connective tissue diseases. This condition is associated with severe pain and can affect the patient’s quality of life and lead to long-term disability. Treatment is often challenging, and there is a very limited evidence base for potential treatments of calcinosis cutis associated with systemic sclerosis and dermatomyositis. Inkless tattoo is very similar to microneedling, a minimally invasive procedure stimulating the wound-healing cascade contributing to elastin and collagen formation as well as neovascularization. This technique has not been reported as a potential therapeutic option for calcinosis cutis. Here, we present a patient with calcinosis cutis in the setting of dermatomyositis that responded dramatically to inkless tattoo application. Our results support the need for future studies of microneedling in patients with this disorder.



中文翻译:

皮肌炎患者无墨纹身后皮肤钙质沉着的消退:微针的治疗潜力

皮肤钙质沉着症被定义为钙盐在皮肤和皮下组织中的异常沉积。营养不良性钙化是最常见的皮肤钙质沉着形式,与自身免疫性结缔组织疾病有关。这种情况与剧烈疼痛有关,会影响患者的生活质量并导致长期残疾。治疗通常具有挑战性,对于与系统性硬化症和皮肌炎相关的皮肤钙质沉着症的潜在治疗,证据基础非常有限。无墨纹身与微针非常相似,微针是一种微创手术,可刺激伤口愈合级联反应,促进弹性蛋白和胶原蛋白的形成以及新血管的形成。该技术尚未被报道为皮肤钙质沉着症的潜在治疗选择。这里,我们介绍了一名患有皮肤钙质沉着症的皮肌炎患者,该患者对无墨纹身应用反应显着。我们的结果支持未来对这种疾病患者进行微针研究的必要性。

更新日期:2022-07-26
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