The aim of this study was to investigate whether pentraxin 3 (PTX3) in microvesicles (MVs) can be a valuable biomarker for the prediction of acute heart failure (AHF) after cardiac surgery with cardiopulmonary bypass (CPB). One hundred and twenty-four patients undergoing cardiac surgery with CPB were included and analyzed (29 with AHF and 95 without AHF). The concentrations of PTX3 in MVs isolated from plasma were measured by ELISA kits before, 12 h, and 3 days after surgery. Patients’ demographics, medical history, surgical data, and laboratory results were collected. The levels of PTX3 in MVs were significantly elevated during perioperative surgery, which was increased more in the AHF group. The concentrations of PTX3 in MVs at postoperative 12 h were independent risk factors for AHF with the area under the ROC curve of 0.920. The concentration of PTX3 in MVs may be a novel biomarker for prediction of AHF after cardiac surgery.

Graphical abstract

中文翻译：

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循环微泡中的 Pentraxin 3：体外循环心脏手术后急性心力衰竭的潜在生物标志物

本研究的目的是研究微泡 (MV) 中的正五聚蛋白 3 (PTX3) 是否可以作为预测体外循环 (CPB) 心脏手术后急性心力衰竭 (AHF) 的有价值的生物标志物。包括并分析了 124 名接受 CPB 心脏手术的患者（29 名患有 AHF，95 名未患有 AHF）。在手术前、12 小时和手术后 3 天，通过 ELISA 试剂盒测量从血浆分离的 MV 中 PTX3 的浓度。收集了患者的人口统计资料、病史、手术数据和实验室结果。围手术期手术期间 MVs 中 PTX3 水平显着升高，AHF 组升高更多。术后12小时MVs中PTX3浓度是AHF的独立危险因素，ROC曲线下面积为0.920。

图形概要