The contribution of related donors to the globally rising number of allogeneic haematopoietic stem cell transplantations (HSCT) remains increasingly important, particularly because of the growing use of haploidentical HSCT. Compared with the strict recommendations on the suitability for unrelated donors, criteria for related donors allow for more discretion and vary between centres. In 2015, the donor outcome committee of the Worldwide Network for Blood and Marrow Transplantation (WBMT) proposed consensus recommendations of suitability criteria for paediatric and adult related donors. This Review provides updates and additions to these recommendations from a panel of experts with global representation, including the WBMT, the European Society for Blood and Marrow Transplantation donor outcome committee, the Center for International Blood and Marrow Transplant Research donor health and safety committee, the US National Marrow Donor Program, and the World Marrow Donor Association, after review of the current literature and guidelines. Sections on the suitability of related donors who would not qualify as unrelated donors have been updated. Sections on communicable diseases, clonal haematopoiesis of indeterminate potential, paediatric aspects including psychological issues, and reporting on serious adverse events have been added. The intention of this Review is to support decision making, with the goal of minimising the medical risk to the donor and protecting the recipient from transmissible diseases.

相关捐赠者对全球同种异体造血干细胞移植 (HSCT) 数量不断增加的贡献仍然越来越重要，特别是因为越来越多地使用单倍体 HSCT。与对无关捐赠者的适用性的严格建议相比，相关捐赠者的标准允许更多的自由裁量权，并且因中心而异。2015 年，全球血液和骨髓移植网络 (WBMT) 的供体结果委员会提出了儿科和成人相关供体适用性标准的共识建议。本审查提供了来自具有全球代表性的专家小组对这些建议的更新和补充，包括 WBMT、欧洲血液和骨髓移植协会捐赠者结果委员会、国际血液和骨髓移植研究中心捐赠者健康和安全委员会、美国国家骨髓捐赠者计划和世界骨髓捐赠者协会，在审查了当前的文献和指南后。更新了有关不符合无关捐赠者资格的相关捐赠者的适用性部分。增加了关于传染病、不确定潜力的克隆性造血、儿科方面（包括心理问题）和严重不良事件报告的部分。本次审查的目的是支持决策制定，目标是最大限度地减少捐赠者的医疗风险并保护接受者免受传染性疾病的侵害。在审查了当前的文献和指南之后。更新了有关不符合无关捐赠者资格的相关捐赠者的适用性部分。增加了关于传染病、不确定潜力的克隆性造血、儿科方面（包括心理问题）和严重不良事件报告的部分。本次审查的目的是支持决策制定，目标是最大限度地减少捐赠者的医疗风险并保护接受者免受传染性疾病的侵害。在审查了当前的文献和指南之后。更新了有关不符合无关捐赠者资格的相关捐赠者的适用性部分。增加了关于传染病、不确定潜力的克隆性造血、儿科方面（包括心理问题）和严重不良事件报告的部分。本次审查的目的是支持决策制定，目标是最大限度地减少捐赠者的医疗风险并保护接受者免受传染性疾病的侵害。并增加了对严重不良事件的报告。本次审查的目的是支持决策制定，目标是最大限度地减少捐赠者的医疗风险并保护接受者免受传染性疾病的侵害。并增加了对严重不良事件的报告。本次审查的目的是支持决策制定，目标是最大限度地减少捐赠者的医疗风险并保护接受者免受传染性疾病的侵害。