Ischemia-reperfusion is a characteristic disorder of many diseases, such as myocardial infarction, stroke, and peripheral vascular diseases. Ischemia-reperfusion injury (IRI) is one of the most frequent causes of debilitating diseases and death. Relieving organ damage caused by IRI is valuable in safeguarding human life and health. In recent years, nanoplatform-based reactive oxygen species (ROS) scavengers have attracted widespread attention for alleviation of IRI. To highlight these achievements and to provide a quick perspective for researchers to understand the current research status, recent progress in nanoplatform-based ROS scavengers for IRI therapy is summarized in this review. This review first summarizes information on the main sites and mechanisms of IRI. Thereafter, this review briefly summarizes and discusses the principles of design, fabrication, and administration of nanoplatform-based ROS scavengers. Furthermore, the application of nanoplatform-based ROS scavengers in the treatment of IRI in a variety of organs is also reviewed. Finally, limitations and possible breakthrough in developing ROS scavengers in the field of IRI are discussed. It is hoped that this review will be helpful and enlightening to researcher in medicine, pharmacy, biology, chemistry, and materials science.

中文翻译：

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基于纳米平台的活性氧清除剂用于治疗缺血再灌注损伤

缺血再灌注是许多疾病的特征性障碍，例如心肌梗塞、中风和外周血管疾病。缺血再灌注损伤 (IRI) 是导致衰弱性疾病和死亡的最常见原因之一。减轻IRI引起的器官损伤对于维护人类生命健康具有重要意义。近年来，基于纳米平台的活性氧（ROS）清除剂在缓解 IRI 方面引起了广泛关注。为了突出这些成就并为研究人员提供一个快速了解当前研究状况的视角，本综述总结了用于 IRI 治疗的基于纳米平台的 ROS 清除剂的最新进展。本综述首先总结了 IRI 的主要站点和机制的信息。此后，本综述简要总结和讨论了设计原则，基于纳米平台的 ROS 清除剂的制造和管理。此外，还综述了基于纳米平台的 ROS 清除剂在治疗各种器官 IRI 中的应用。最后，讨论了在 IRI 领域开发 ROS 清除剂的局限性和可能的​​突破。希望本综述对医学、药学、生物学、化学、材料科学等领域的研究人员有所帮助和启发。