Chronic recurrent multifocal osteomyelitis (CRMO) is an idiopathic autoinflammatory disease of the bone that typically occurs in children and adolescents. CRMO is characterized by recurrent periods of exacerbation and remission of symptomatic, osteolytic/sclerotic sterile bone lesions and is often a diagnosis of exclusion. Treatment consists of multimodal anti-inflammatory medication management by rheumatology and rarely involves surgery. This review summarizes the clinical presentation, pathophysiology, diagnosis, and management of this disease and highlights the role of the orthopedic surgeon. With increased familiarity with CRMO, clinicians will be able to diagnose and treat the condition in a more timely manner. [Orthopedics. 202x;4x(x):xx–xx.]

慢性复发性多灶性骨髓炎 (CRMO) 是一种特发性自身炎症性骨骼疾病，通常发生在儿童和青少年中。CRMO 的特征是有症状的溶骨性/硬化性无菌性骨病变反复加重和缓解，通常是一种排除性诊断。治疗包括风湿病学的多模式抗炎药物管理，很少涉及手术。这篇综述总结了这种疾病的临床表现、病理生理学、诊断和治疗，并强调了骨科医生的作用。随着对 CRMO 的熟悉程度的提高，临床医生将能够更及时地诊断和治疗该病症。[骨科。202x;4x(x):xx–xx.]