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Effects of an art-based intervention in older adults with mild cognitive impairment: a randomised controlled trial
Age and Ageing ( IF 6.7 ) Pub Date : 2022-07-24 , DOI: 10.1093/ageing/afac144
Rong Lin 1, 2 , Yu-Ting Luo 2 , Yuan-Jiao Yan 2 , Chen-Shan Huang 2 , Li-Li Chen 1, 2 , Ming-Feng Chen 3 , Mo-Jun Lin 4 , Hong Li 1, 2
Affiliation  

Background Art-based interventions may delay cognitive decline and improve health-related outcomes in older adults with mild cognitive impairment (MCI). Objective To examine the effects of the Creative Expressive Arts-based Storytelling (CrEAS) program compared to active and waitlist controls on neurocognitive and other health-related outcomes in older people with MCI. Design Three-arm parallel-group, randomised controlled design. Participants One-hundred and thirty-five adults with MCI (mean age: 70.93 ± 6.91 years). Methods Participants were randomly assigned to intervention (CrEAS, n = 45), active control (n = 45) or waitlist control (n = 45) groups. Interventions were applied once per week for 24 weeks. The primary outcome was global cognitive function; secondary outcomes were specific cognition domains (memory, executive function, language and attention) and other health-related outcomes (anxiety, depression and quality of life [QoL]). All variables were measured at baseline (T0), 24-week follow-up (T1) and 48-week follow-up (T2). Results Participants in the CrEAS group showed significantly higher global cognitive function (adjusted mean difference [MD] = −0.905, 95% confidence interval [CI] −1.748 to −0.062; P = 0.038) and QoL (adjusted MD = −4.150, 95% CI -6.447 to −1.853; P = 0.001) and lower depression symptoms (adjusted MD = 2.902, 95% CI 0.699–5.104; P = 0.011) post-intervention at the 24-week follow-up compared with the active control group. At 48-week follow-up, only the Auditory Verbal Learning Test Immediate recall score was significantly improved compared with the active control group (adjusted MD = −2.941, 95% CI −5.262 to −0.620; P = 0.014). Conclusions Older adults with MCI who participated in the CrEAS program improved their neuropsychological outcomes and QoL and reduced their rate of cognitive deterioration.

中文翻译:

基于艺术的干预对轻度认知障碍老年人的影响:一项随机对照试验

背景 基于艺术的干预可能会延缓轻度认知障碍 (MCI) 老年人的认知能力下降并改善与健康相关的结果。目的 比较以创造性表达艺术为基础的讲故事 (CrEAS) 计划与积极和候补名单控制相比,对患有 MCI 的老年人的神经认知和其他健康相关结果的影响。设计 三臂平行组、随机对照设计。参与者 135 名患有 MCI 的成年人(平均年龄:70.93 ± 6.91 岁)。方法 参与者被随机分配到干预组(CrEAS,n = 45)、主动控制组(n = 45)或候补名单控制组(n = 45)。每周进行一次干预,持续 24 周。主要结果是整体认知功能;次要结果是特定的认知领域(记忆、执行功能、语言和注意力)和其他与健康相关的结果(焦虑、抑郁和生活质量 [QoL])。所有变量均在基线 (T0)、24 周随访 (T1) 和 48 周随访 (T2) 进行测量。结果 CrEAS 组的参与者显示出显着更高的整体认知功能(调整后的平均差 [MD] = -0.905, 95% 置信区间 [CI] -1.748 至 -0.062;P = 0.038)和生活质量(调整后的 MD = -4.150, 95 % CI -6.447 至 -1.853;P = 0.001)和较低的抑郁症状(调整后的 MD = 2.902, 95% CI 0.699–5.104;P = 0.011)干预后 24 周随访与积极对照组相比. 在 48 周的随访中,与主动对照组相比,只有听觉语言学习测试即时回忆评分显着提高(调整后的 MD = -2.941,95% CI -5.262 至 -0.620;P = 0.014)。
更新日期:2022-07-24
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