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Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients?
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2022-07-23 , DOI: 10.1016/j.etap.2022.103937
Ayse Basak Engin 1 , Evren Doruk Engin 2 , Atilla Engin 3
Affiliation  

In severe COVID-19, the levels of iron (Fe), copper (Cu), zinc (Zn) and selenium (Se), do not only regulate host immune responses, but modify the viral genome, as well. While low serum Fe concentration is an independent risk factor for the increased death rate, Zn controls oxidative stress, synthesis of inflammatory cytokines and viral replication. Therefore, Zn deficiency associates with a worse prognosis. Although Cu exposure inactivates the viral genome and exhibits spike protein dispersal, increase in Cu/Zn due to high serum Cu levels, are correlated with enhanced risk of infections. Se levels are significantly higher in surviving COVID-19 patients. Meanwhile, both Zn and Se suppress the replication of SARS-CoV-2. Since the balance between the deficiency and oversupply of these metals due to a reciprocal relationship, has decisive effect on the prognosis of the SARS-CoV-2 infection, monitoring their concentrations may facilitate improved outcomes for patients suffering from COVID-19.



中文翻译:

铁、锌、铜和硒的状态能否成为 COVID-19 患者的预后决定因素?

在严重的 COVID-19 中,铁 (Fe)、铜 (Cu)、锌 (Zn) 和硒 (Se) 的水平不仅调节宿主免疫反应,而且还修饰病毒基因组。虽然低血清铁浓度是死亡率增加的独立危险因素,但锌控制氧化应激、炎性细胞因子的合成和病毒复制。因此,缺锌与较差的预后相关。尽管 Cu 暴露会使病毒基因组失活并表现出刺突蛋白扩散,但由于高血清 Cu 水平导致的 Cu/Zn 增加与感染风险增加相关。幸存的 COVID-19 患者的 Se 水平明显更高。同时,Zn 和 Se 都抑制 SARS-CoV-2 的复制。由于这些金属的供应不足和供应过剩之间的平衡是一种互惠关系,

更新日期:2022-07-23
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