This study aimed to synthesize a new pyrimidine derivative with a good synthesis yield of 87% to act as a new cancer marker after radiolabeling with Tc-99m in a high radiochemical yield of 92.3%. In-vivo study in tumor-bearing Swiss albino mice model revealed promising data with high uptake in cancer. Docking study showed good binding interactions of the radiosynthesized complex at the binding site. In conclusion, this novel complex could be a potential probe for cancer targeting.

中文翻译：

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6-氨基-5-[(双-(2-羟基-乙基)-氨基]甲基]2-甲基嘧啶-4-醇作为潜在探针的合成、99mTc标记、体内研究和计算机研究用于肿瘤靶向

本研究旨在合成一种新的嘧啶衍生物，其合成收率高达 87%，可作为一种新的癌症标志物，经 Tc-99m 放射性标记后，放射化学收率高达 92.3%。荷瘤瑞士白化小鼠模型的体内研究揭示了癌症高摄取的有希望的数据。对接研究表明，放射性合成的复合物在结合位点具有良好的结合相互作用。总之，这种新型复合物可能是癌症靶向的潜在探针。