Safety and efficacy of istaroxime in patients with acute heart failure-related pre-cardiogenic shock – a multicentre, randomized, double-blind, placebo-controlled, parallel group study (SEISMiC),European Journal of Heart Failure

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Safety and efficacy of istaroxime in patients with acute heart failure-related pre-cardiogenic shock – a multicentre, randomized, double-blind, placebo-controlled, parallel group study (SEISMiC)
European Journal of Heart Failure ( IF 18.2 ) Pub Date : 2022-07-22 , DOI: 10.1002/ejhf.2629
Marco Metra ₁ , Ovidiu Chioncel _{2,

3} , Gad Cotter _{4,

5} , Beth Davison _{4,

5} , Gerasimos Filippatos ₆ , Alexandre Mebazaa _{5,

7} , Maria Novosadova ₄ , Piotr Ponikowski ₈ , Phillip Simmons ₉ , Joseph Soffer ₉ , Steven Simonson ₉

Affiliation

Cardiology Unit, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Emergency Institute for Cardiovascular Diseases 'Prof. C.C. Iliescu', Bucharest, Romania.
University of Medicine Carol Davila, Bucharest, Romania.
Momentum Research, Inc, Chapel Hill, NC, USA.
Cardiovascular Markers in Stress Conditions (MASCOT), Université Paris Cité; Inserm UMR-S 942, Paris, France.
Department of Cardiology, University of Cyprus, School of Medicine & National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece.
Department of Anesthesiology and Critical Care and Burn Unit, Hôpital Saint-Louis Lariboisière, FHU PROMICE, DMU Parabol, APHP.Nord, Paris, France.
Department of Heart Diseases, Wroclaw Medical University, Wrocław, Poland.
Windtree Therapeutics, Inc., Warrington, PA, USA.

We examined the effects of istaroxime in patients hospitalized for acute heart failure (AHF) related Society for Cardiovascular Angiography and Interventions (SCAI) stage B pre-cardiogenic shock (CS).

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