ABSTRACT

The human intestine hosts diverse microbial communities that play a significant role in maintaining gut-skin homeostasis. When the relationship between gut microbiome and the immune system is impaired, subsequent effects can be triggered on the skin, potentially promoting the development of skin diseases. The mechanisms through which the gut microbiome affects skin health are still unclear. Enhancing our understanding on the connection between skin and gut microbiome is needed to find novel ways to treat human skin disorders. In this review, we systematically evaluate current data regarding microbial ecology of healthy skin and gut, diet, pre- and probiotics, and antibiotics, on gut microbiome and their effects on skin health. We discuss potential mechanisms of the gut-skin axis and the link between the gut and skin-associated diseases, such as psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, and hidradenitis suppurativa. This review will increase our understanding of the impacts of gut microbiome on skin conditions to aid in finding new medications for skin-associated diseases.

摘要

人类肠道拥有多种微生物群落，在维持肠道-皮肤稳态方面发挥着重要作用。当肠道微生物群与免疫系统之间的关系受损时，可能会对皮肤产生后续影响，可能促进皮肤病的发展。肠道微生物群影响皮肤健康的机制仍不清楚。需要加强我们对皮肤和肠道微生物组之间联系的理解，以找到治疗人类皮肤疾病的新方法。在这篇综述中，我们系统地评估了有关健康皮肤和肠道微生物生态学、饮食、益生菌和抗生素、肠道微生物组及其对皮肤健康影响的当前数据。我们讨论肠道-皮肤轴的潜在机制以及肠道与皮肤相关疾病之间的联系，例如牛皮癣、特应性皮炎、寻常痤疮、酒渣鼻、斑秃和化脓性汗腺炎。这篇综述将加深我们对肠道微生物组对皮肤状况影响的了解，以帮助寻找治疗皮肤相关疾病的新药物。