Abstract

In this paper we develop the fundamentals of a promising method of magnetoluminescent theranostics of tumors with visually and endoscopically accessible localization. The method is based on the use of composite nanoparticles consisting of a Lexan-type polymer matrix (nanocomposite shell) with incorporated ytterbium complexes of porphyrins (a hydrophobic ytterbium complex of hematoporphyrin IX tetramethyl ether), as well as magnetite nanoparticles. In this case, nanoparticles of the ytterbium porphyrin complex incorporated into the polymer matrix are responsible for carrying out the process of luminescent tumor diagnostics while magnetite nanoparticles provide tumor therapy through magnetic hyperthermia. The optimal size range of magnetic nanoparticles used in this method is shown to be d = 10–20 nm. Studies on the biodistribution of the nanocomposite in various organs and tumors of laboratory animals (female mice of the Bulb/c line with transplanted Ehrlich carcinoma) showed a significant selectivity of the accumulation of nanoparticles in the tumor as early as 24 h after intravenous administration.

中文翻译：

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基于卟啉和磁铁矿纳米粒子的镱配合物的癌症磁致发光治疗学

摘要

在本文中，我们开发了一种有前途的肿瘤磁致发光治疗诊断方法的基础，该方法具有视觉和内窥镜可访问的定位。该方法基于使用由 Lexan 型聚合物基质（纳米复合壳）和掺入的卟啉镱复合物（血卟啉 IX 四甲醚的疏水性镱复合物）以及磁铁矿纳米颗粒组成的复合纳米颗粒。在这种情况下，掺入聚合物基质中的镱卟啉复合物纳米颗粒负责执行发光肿瘤诊断过程，而磁铁矿纳米颗粒通过磁热疗提供肿瘤治疗。该方法中使用的磁性纳米粒子的最佳尺寸范围为d= 10-20 纳米。纳米复合材料在实验动物（移植埃利希氏癌的 Bulb/c 系雌性小鼠）的各种器官和肿瘤中的生物分布研究表明，在静脉给药后 24 小时，纳米颗粒在肿瘤中的积累具有显着的选择性。