Knowledge of dasatinib-induced nephrotic syndrome is largely based on case reports. The clinical features of dasatinib-induced nephrotic syndrome are unknown. We collected case reports of 25 patients with nephrotic syndrome and analyzed their clinical characteristics. Overall, the onset of nephrotic syndrome ranged from 10 days to 5 years after dasatinib administration. Nine patients (36.0%) had clinical symptoms, mainly periorbital edema and lower-extremity edema. Serum albumin ranged from 1.2 g/dL to 3.7 g/dL in 10 patients (38.5%). The 24-h urine protein values ranged from 3.54 g/day to 118 g/day. Kidney biopsy of 13 patients (52.0%) mainly showed focal foot process effacement, mesangial hyperplasia, endothelial cell damage and focal segmental glomerulosclerosis. Proteinuria resolved or recovered after dasatinib discontinuation or dose reduction or switching to other tyrosine kinase inhibitors (TKIs).

达沙替尼诱发的肾病综合征的知识主要基于病例报告。达沙替尼诱发的肾病综合征的临床特征尚不清楚。我们收集了 25 例肾病综合征患者的病例报告，并分析了他们的临床特征。总体而言，肾病综合征的发作范围为达沙替尼给药后 10 天至 5 年。9例（36.0%）有临床症状，主要为眶周水肿和下肢水肿。10 名患者 (38.5%) 的血清白蛋白范围为 1.2 g/dL 至 3.7 g/dL。24 小时尿蛋白值范围为 3.54 克/天至 118 克/天。13例（52.0%）肾活检主要表现为局灶性足突消失、系膜增生、内皮细胞损伤和局灶节段性肾小球硬化。