A one-pot Cu-mediated H–D exchange with inexpensive heavy water as the deuterium source, followed by Cu- and Ir-catalyzed stereodivergent allylic alkylation, has been developed, providing efficient access to enantioenriched α-deuterium-labeled α-amino acids from readily available glycine imine esters in a high yield with excellent stereoselectivity. High deuterium enrichment, exquisite regioselectivity, precise stereoselectivity control, and operationally convenient procedures make this protocol appealing for the preparation of highly synthetically useful α-deuterated α-amino acids.

中文翻译：

---

级联 Cu(I) 催化 H-D 交换和双铜和铱催化烯丙基化立体发散合成对映体富集的 α-氘代 α-氨基酸

已经开发了一种以廉价重水为氘源的一锅式 Cu 介导的 H-D 交换，然后是 Cu 和 Ir 催化的立体发散烯丙基烷基化，为获得对映体富集的 α-氘标记的 α-氨基酸提供了有效途径从容易获得的甘氨酸亚胺酯中以高收率和优异的立体选择性制备。高氘富集、精细的区域选择性、精确的立体选择性控制和操作方便的程序使该协议对制备高度合成有用的 α-氘代 α-氨基酸具有吸引力。