Developing broad-spectrum, host-directed antiviral therapeutics can be adapted to combat emerging viruses. In this issue of Cell Chemical Biology, Maarifi and colleagues implement a Nano luciferase reporter-based protein complementation assay to screen for small molecules and identify Gilteritinib, which enhances interferon induction and antagonizes virus replication.

中文翻译：

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照亮宿主导向免疫疗法的道路

开发广谱、宿主导向的抗病毒疗法可以适应新出现的病毒。在本期Cell Chemical Biology中，Maarifi 及其同事实施了一种基于纳米荧光素酶报告基因的蛋白质互补测定法，以筛选小分子并鉴定 Gilteritinib，后者可增强干扰素诱导并拮抗病毒复制。