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Recent developments in the computational simulation of dry powder inhalers
Advanced Drug Delivery Reviews ( IF 16.1 ) Pub Date : 2022-07-20 , DOI: 10.1016/j.addr.2022.114461
Jesse Capecelatro 1 , Worth Longest 2 , Connor Boerman 3 , Mostafa Sulaiman 4 , Sankaran Sundaresan 4
Affiliation  

This article reviews recent developments in computational modeling of dry powder inhalers (DPIs). DPIs deliver drug formulations (sometimes blended with larger carrier particles) to a patient’s lungs via inhalation. Inhaler design is complicated by the need for maximum aerosolization efficiency, which is favored by high levels of turbulence near the mouthpiece, with low extrathoracic depositional loss, which requires low turbulence levels near the mouth-throat region. In this article, we review the physical processes contributing to aerosolization and subsequent dispersion and deposition. We assess the performance characteristics of DPIs using existing simulation techniques and offer a perspective on how such simulations can be improved to capture the physical processes occurring over a wide range of length- and timescales more efficiently.



中文翻译:

干粉吸入器计算模拟的最新进展

本文回顾了干粉吸入器 (DPI) 计算建模的最新进展。DPI 通过吸入将药物制剂(有时与较大的载体颗粒混合)输送到患者的肺部。吸入器设计因需要最大雾化效率而变得复杂,吸嘴附近的高水平湍流有利于吸入器设计,而胸腔外沉积损失低,这需要嘴-喉区域附近的低湍流水平。在这篇文章中,我们回顾了有助于雾化和随后的分散和沉积的物理过程。我们使用现有的模拟技术评估 DPI 的性能特征,并就如何改进此类模拟以更有效地捕获在广泛的长度和时间范围内发生的物理过程提供了一个视角。

更新日期:2022-07-25
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