Background

To study differences in oxidative stress markers and antioxidants among patients with bipolar depression (BPD) and unipolar depression (UPD).

Methods

Data sources. Electronic MEDLINE/PubMed/Cochrane Library/Scopus/TripDatabase database search until 30/06/2021.

Study selection. Included were articles comparing antioxidant or oxidative stress markers between adults with BPD or UPD and healthy controls (HCs).

Data extraction. Two authors extracted data independently. Random effects meta-analysis, calculating standardized mean differences for results from ≥3 studies.

Results

Oxidative stress markers reported in 40 studies −1 published repeatedly– (UPD, studies = 30 n = 3072; their HCs, n = 2856; BPD, studies = 11 n = 393; their HCs, n = 540; with 1 study reporting on both UPD and BPD) included thiobarbituric acid reactive substances (TBARS), antioxidant uric acid and antioxidant-enhancing enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione-peroxidase (GPX).

Compared with HCs, UPD and BPD were associated with significantly higher levels of TBARS, without differences between UPD and BPD (P = 0.11). Compared with HCs, UPD and BPD did not differ regarding the activity of the CAT (P = 0.28), SOD (P = 0.87) and GPX (P = 0.25) enzymes. However, uric acid levels were significantly higher vs HCs in BPD than in UPD among adult patients (P = 0.004). Results were heterogenous, which, for some parameters, decreased after stratification by the blood source (serum, plasma red blood cells, whole blood).

Limitations

The main limitations are the small number of studies/participants in the BPD subgroup, and heterogeneity of the results.

Summations

Both BPD and UPD may be associated with an impaired oxidative stress balance, with significantly higher uric acid levels vs. HCs in UPD than in BPD.

中文翻译：

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单相或双相抑郁症成人与健康对照者的氧化应激参数和抗氧化剂：系统评价和荟萃分析

背景

研究双相抑郁症（BPD）和单相抑郁症（UPD）患者氧化应激标志物和抗氧化剂的差异。

方法

数据源。电子 MEDLINE/PubMed/Cochrane 图书馆/Scopus/TripDatabase 数据库搜索，直到 2021 年 6 月 30 日。

研究选择。包括比较患有 BPD 或 UPD 的成年人与健康对照 (HC) 之间的抗氧化或氧化应激标志物的文章。

数据提取。两位作者独立提取数据。随机效应荟萃分析，计算≥3 项研究结果的标准化平均差。

结果

在 40 项研究中报告的氧化应激标记物 −1 重复发表——（UPD，研究 = 30 n  = 3072；他们的 HC，n  = 2856；BPD，研究 = 11 n  = 393；他们的 HC，n  = 540；有 1 项研究报告了UPD 和 BPD) 包括硫代巴比妥酸反应物质 (TBARS)、抗氧化尿酸和抗氧化增强酶超氧化物歧化酶 (SOD)、过氧化氢酶 (CAT) 和谷胱甘肽过氧化物酶 (GPX)。

与 HCs 相比，UPD 和 BPD 与 TBARS 水平显着升高相关，UPD 和 BPD 之间没有差异（P  = 0.11）。与 HCs 相比，UPD 和 BPD 在 CAT ( P  = 0.28)、SOD ( P  = 0.87) 和 GPX ( P  = 0.25) 酶的活性方面没有差异。然而，在成年患者中，BPD 患者的尿酸水平与 HCs 相比显着高于 UPD（P  = 0.004）。结果是异质的，对于某些参数，在按血源（血清、血浆红细胞、全血）分层后降低。

限制

主要限制是 BPD 亚组中的研究/参与者数量少，以及结果的异质性。

总结

BPD 和 UPD 都可能与氧化应激平衡受损有关，与 BPD 相比，UPD 中的尿酸水平明显高于 HC。