In this issue, Kaneko et al. reported the generation of a mouse line that allows for the labeling of cells under control of the erythropoietin (Epo) gene promotor. The authors show that Epo-producing cells become proliferating, profibrotic cells after kidney injury and lose their ability to produce Epo. Furthermore, they show that the fluorescent-labeled cells can recover their Epo synthesis capability subsequently to a recovery period.

中文翻译：

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促红细胞生成素细胞的命运：另一个难题

在这个问题上，Kaneko等人。报道了一种小鼠系的产生，该系允许在促红细胞生成素（Epo）基因启动子的控制下标记细胞。作者表明，在肾损伤后，产生 Epo 的细胞会变成增殖的促纤维化细胞，并失去产生 Epo 的能力。此外，他们表明荧光标记的细胞可以在恢复期后恢复其 Epo 合成能力。