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Protective effect of melatonin and carnosine against radiation induced kidney injury
Journal of Radioanalytical and Nuclear Chemistry ( IF 1.6 ) Pub Date : 2022-07-19 , DOI: 10.1007/s10967-022-08419-6
Ismet Burcu Turkyilmaz , Huseyin Us , Ayca Sezen Us , Omur Karabulut-Bulan , Refiye Yanardag

We designed this study to determine possible protective roles of melatonin and carnosine on radiation. Wistar albino rats were divided to five groups. Melatonin, carnosine and combinated version were injected to Group III, IV and V every 48 h in a week. Group II, III, IV and V were exposed to 8 Gy gamma radiation dose arranged for whole-body one hour later second injection. Degenerative and biochemical changes were determined in radiation group as compared to control group. Administration of melatonin, carnosine and their combination ameliorated these parameters. We can conclude melatonin, carnosine and their combination protect kidney against radiation.



中文翻译:

褪黑素和肌肽对放射性肾损伤的保护作用

我们设计了这项研究来确定褪黑激素和肌肽对辐射的可能保护作用。Wistar白化大鼠分为五组。每周每 48 小时向 III、IV 和 V 组注射褪黑激素、肌肽和组合版本。II、III、IV 和 V 组暴露于 8 Gy γ 辐射剂量,安排为一小时后第二次注射全身。与对照组相比,在放射组中测定了退行性和生化变化。褪黑激素、肌肽及其组合的施用改善了这些参数。我们可以得出结论,褪黑激素、肌肽及其组合可以保护肾脏免受辐射。

更新日期:2022-07-20
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