Molecular Psychiatry ( IF 11.0 ) Pub Date : 2022-07-20 , DOI: 10.1038/s41380-022-01698-1 Suzanne D Lanooij 1 , Ulrich L M Eisel 1 , Wilhelmus H I M Drinkenburg 1, 2 , Eddy A van der Zee 1 , Martien J H Kas 1
Many psychiatric and neurological disorders present deficits in both the social and cognitive domain. In this perspectives article, we provide an overview and the potential of the existence of an extensive neurobiological substrate underlying the close relationship between these two domains. By mapping the rodent brain regions involved in the social and/or cognitive domain, we show that the vast majority of brain regions involved in the cognitive domain are also involved in the social domain. The identified neuroanatomical overlap has an evolutionary basis, as complex social behavior requires cognitive skills, and aligns with the reported functional interactions of processes underlying cognitive and social performance. Based on the neuroanatomical mapping, recent (pre-)clinical findings, and the evolutionary perspective, we emphasize that the social domain requires more focus as an important treatment target and/or biomarker, especially considering the presently limited treatment strategies for these disorders.
中文翻译:
通过社交互动影响认知表现:一种基于神经解剖学映射的脑部疾病治疗新方法?
许多精神和神经系统疾病在社交和认知领域都存在缺陷。在这篇观点文章中,我们概述了这两个领域之间密切关系背后广泛的神经生物学基质的存在潜力。通过绘制涉及社会和/或认知领域的啮齿动物大脑区域,我们表明绝大多数涉及认知领域的大脑区域也涉及社会领域。已确定的神经解剖学重叠具有进化基础,因为复杂的社会行为需要认知技能,并且与报告的认知和社会表现过程的功能相互作用相一致。基于神经解剖学映射、最近(前)临床发现和进化观点,