Correlations of Full-Field Stimulus Threshold With Functional and Anatomical Outcome Measurements in Advanced Retinitis Pigmentosa,American Journal of Ophthalmology

当前位置： X-MOL 学术 › Am. J. Ophthalmol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Correlations of Full-Field Stimulus Threshold With Functional and Anatomical Outcome Measurements in Advanced Retinitis Pigmentosa
American Journal of Ophthalmology ( IF 4.2 ) Pub Date : 2022-07-20 , DOI: 10.1016/j.ajo.2022.07.010
Wei Kiong Ngo ₁ , Laura A Jenny ₂ , Angela H Kim ₃ , Masha Kolesnikova ₃ , Vivienne C Greenstein ₄ , Stephen H Tsang ₅

Affiliation

From the Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, USA; Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Department of Ophthalmology, Columbia University, New York, New York, USA; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
From the Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, USA; Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Department of Ophthalmology, Columbia University, New York, New York, USA.
From the Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, USA; Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Department of Ophthalmology, Columbia University, New York, New York, USA; College of Medicine at the State University of New York at Downstate Medical Center, Brooklyn.
From the Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, USA.
From the Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, USA; Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Department of Ophthalmology, Columbia University, New York, New York, USA; Department of Pathology & Cell Biology, Institute of Human Nutrition, Columbia Stem Cell Initiative, Columbia University, New York, New York, USA.

Purpose

To compare full-field stimulus (FST) threshold values to conventional functional and anatomical measures commonly used in clinical practice.

Design

Cross-sectional study.

Methods

Patients with retinitis pigmentosa with nondetectable electroretinogram rod–mediated responses and light-adapted 3.0 cd·s·m² 30-Hz flicker (LA 3.0 flicker) amplitudes of 15 mV or less were included in this study. The threshold values for blue, white, and red stimuli on FST were correlated with best-corrected visual acuity, LA 3.0 flicker amplitude and implicit times, length of the ellipsoid zone (EZ) band and thickness of outer nuclear layer measurements on optical coherence tomography, and the vertical and horizontal diameters of the autofluorescent ring on autofluorescence imaging.

Results

Forty-two eyes of 21 patients were included in the study. The mean FST thresholds were −22.5 ± 15.5 dB, −17.6 ± 11.5 dB, and −12.7 ± 6.0 dB for the blue, white, and red stimuli, respectively. The threshold values for the 3 FST stimuli were significantly correlated with selected functional and anatomical outcome measures. Specifically, they were strongly correlated with LA 3.0 flicker amplitude and EZ band length measured on optical coherence tomography. Using linear regression, blue and white stimulus values on FST were found to be predictive of EZ band length (R² = 0.579 and 0.491, respectively), and the vertical (R² = 0.694 and 0.532, respectively) and horizontal (R² = 0.626 and 0.400, respectively) diameters of the hyperautofluorescent ring.

Conclusions

The significant correlations between FST and other clinical outcome measures highlight its potential as an adjunct outcome measure.

中文翻译：

全场刺激阈值与晚期视网膜色素变性的功能和解剖结果测量的相关性

目的

将全场刺激 (FST) 阈值与临床实践中常用的常规功能和解剖测量值进行比较。

设计

横断面研究。

方法

本研究包括具有无法检测到的视网膜电图杆介导反应和 15 mV 或更小的光适应 3.0 cd·s·m ^{2 30-Hz 闪烁（LA 3.0 闪烁）振幅的视网膜色素变性患者。}FST 上蓝色、白色和红色刺激的阈值与最佳矫正视力、LA 3.0 闪烁幅度和隐式时间、椭球带 (EZ) 带长度和光学相干断层扫描外核层测量厚度相关, 以及自发荧光成像中自发荧光环的垂直和水平直径。

结果

该研究包括 21 名患者的 42 只眼睛。蓝色、白色和红色刺激的平均 FST 阈值分别为 -22.5 ± 15.5 dB、-17.6 ± 11.5 dB 和 -12.7 ± 6.0 dB。3 个 FST 刺激的阈值与选定的功能和解剖学结果测量显着相关。具体而言，它们与光学相干断层扫描测量的 LA 3.0 闪烁幅度和 EZ 带长度密切相关。使用线性回归，发现 FST 上的蓝色和白色刺激值可预测 EZ 波段长度（分别为 R ² = 0.579 和 0.491），以及垂直（分别为 R ² = 0.694 和 0.532）和水平（R ² = 0.626 和 0.400，分别）超自发荧光环的直径。