Abstract

Platelets play a role in hemostasis, thrombosis, and vascular integrity. They also play a major role in the development of inflammation and the activation of immune responses. They have phagocytic activity, stimulate the secretion of immune modulators, and activate other immune cells, which results in platelet-neutrophil aggregation, platelet-induced neutrophil degranulation, and the formation of neutrophil extracellular traps. Data on 124 febrile neutropenia attacks were retrospectively examined. Patients’ age, sex, diagnosis, and relapse history were obtained. The complete blood count levels on the first and last febrile day of the febrile neutropenia attacks, duration of fever, and number, type, and timing of thrombocyte suspension transfusions were recorded. The patients were divided into three groups according to the day of fever when the platelet suspension was administered (1 day, 2–3 days, and >3 days); the duration of fever was compared between the three groups. The fever duration of those who were transfused with platelet suspension on the first day of fever was found to be significantly shorter (p = 0.03 and p < 0.001, respectively). When treating a patient with febrile neutropenia, if thrombocyte suspension transfusion is indicated, transfusing thrombocytes in the first days of fever shortens the fever duration and improves the prognosis of febrile neutropenia attack, supporting the hypothesis that not only neutrophils but also platelets may play a role in fighting against microorganisms.

摘要

血小板在止血、血栓形成和血管完整性中发挥作用。它们还在炎症的发展和免疫反应的激活中发挥重要作用。它们具有吞噬活性，刺激免疫调节剂的分泌，并激活其他免疫细胞，导致血小板-中性粒细胞聚集，血小板诱导的中性粒细胞脱粒，形成中性粒细胞胞外陷阱。回顾性检查了 124 例发热性中性粒细胞减少症发作的数据。获得患者的年龄、性别、诊断和复发史。记录发热性中性粒细胞减少症发作的第一个和最后一个发热日的全血细胞计数水平、发热持续时间以及血小板悬浮液输注的次数、类型和时间。根据给予血小板悬液时的发热天数将患者分为三组（1天、2～3天、>3天）；比较三组发热持续时间。发现发热第一天输注血小板悬浮液的患者发热持续时间明显缩短。p  = 0.03 和p  < 0.001，分别）。在治疗发热性中性粒细胞减少症患者时，如果需要输注血小板悬液，则在发热的最初几天输注血小板可缩短发热持续时间并改善发热性中性粒细胞减少症发作的预后，支持不仅中性粒细胞而且血小板可能起作用的假设在对抗微生物方面。