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Genomic evidence that a sexually selected trait captures genome-wide variation and facilitates the purging of genetic load
Nature Ecology & Evolution ( IF 16.8 ) Pub Date : 2022-07-18 , DOI: 10.1038/s41559-022-01816-w
Jonathan M Parrett 1 , Sebastian Chmielewski 1 , Eylem Aydogdu 2, 3, 4 , Aleksandra Łukasiewicz 1, 5 , Stephane Rombauts 2, 3, 4 , Agnieszka Szubert-Kruszyńska 1 , Wiesław Babik 6 , Mateusz Konczal 1 , Jacek Radwan 1
Affiliation  

The evolution of costly traits such as deer antlers and peacock trains, which drove the formation of Darwinian sexual selection theory, has been suggested to both reflect and affect patterns of genetic variance across the genome, but direct tests are missing. Here, we used an evolve and resequence approach to reveal patterns of genome-wide diversity associated with the expression of a sexually selected weapon that is dimorphic among males of the bulb mite, Rhizoglyphus robini. Populations selected for the weapon showed reduced genome-wide diversity compared to populations selected against the weapon, particularly in terms of the number of segregating non-synonymous positions, indicating enhanced purifying selection. This increased purifying selection reduced inbreeding depression, but outbred female fitness did not improve, possibly because any benefits were offset by increased sexual antagonism. Most single nucleotide polymorphisms (SNPs) that consistently diverged in response to selection were initially rare and overrepresented in exons, and enriched in regions under balancing or relaxed selection, suggesting they are probably moderately deleterious variants. These diverged SNPs were scattered across the genome, further demonstrating that selection for or against the weapon and the associated changes to the mating system can both capture and influence genome-wide variation.



中文翻译:

基因组学证据表明,性选择的性状捕获全基因组变异并促进遗传负荷的清除

鹿角和孔雀尾巴等昂贵性状的进化推动了达尔文性选择理论的形成,有人认为它们既能反映又能影响整个基因组的遗传变异模式,但缺少直接测试。在这里,我们使用进化和重测序方法来揭示与性选择武器的表达相关的全基因组多样性模式,这种武器在球茎螨Rhizoglyphus robini的雄性中是二态的. 与针对武器选择的种群相比,为武器选择的种群显示全基因组多样性减少,特别是在分离非同义位置的数量方面,表明增强的净化选择。这种增加的净化选择减少了近亲繁殖的抑制,但近亲繁殖的雌性健康状况没有改善,这可能是因为任何好处都被增加的性对抗所抵消。大多数响应选择而持续分化的单核苷酸多态性 (SNP) 最初是罕见的,并且在外显子中过多,并且在平衡或宽松选择下的区域富集,表明它们可能是中度有害的变体。这些不同的 SNP 散布在整个基因组中,

更新日期:2022-07-19
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