Lyme borreliosis affects the nervous system in three principal ways—mononuclear cell meningitis, cranial neuropathies and radiculoneuropathies—the last a broad term encompassing painful radiculopathy, unifocal and multifocal peripheral nerve involvement. Diagnostic tools have been significantly refined—including improved peripheral blood and CSF serodiagnostics—and much has been learned about the interactions between the causative pathogen and the nervous system. Despite these advances in our understanding of this disease, a broad range of other disorders continue to be misattributed to nervous system Lyme borreliosis, supported by, at best, limited evidence. These misattributions often reflect limited understanding not only of Lyme neuroborreliosis but also of what constitutes nervous system disease generally. Fortunately, a large body of evidence now exists to clarify many of these issues, establishing a clear basis for diagnosing nervous system involvement in this infection and, based on well performed studies, clarifying which clinical disorders are associated with Lyme neuroborreliosis, which with non-neurologic Lyme borreliosis, and which with neither.

中文翻译：

---

莱姆神经疏螺旋体病：已知已知，已知未知

莱姆疏螺旋体病以三种主要方式影响神经系统——单核细胞脑膜炎、颅神经病和神经根神经病——最后一个广义术语包括疼痛性神经根病、单灶性和多灶性周围神经受累。诊断工具已经显着改进——包括改进的外周血和脑脊液血清诊断——并且已经了解了很多关于致病病原体和神经系统之间相互作用的知识。尽管我们对这种疾病的理解取得了这些进展，但许多其他疾病仍然被错误地归因于神经系统莱姆疏螺旋体病，充其量只是有限的证据支持。这些错误归因往往不仅反映了对莱姆神经疏螺旋体病的有限了解，而且也反映了对一般构成神经系统疾病的认识有限。幸运的是，