Objective

Correlations between cognitive ability and psychopathology are well recognized, but prior research has been limited by focusing on individuals with intellectual disability, single-diagnosis psychiatric populations, or few measures of psychopathology. Here, we quantify relationships between full-scale IQ and multiple dimensions of psychopathology in a diverse care-seeking population, with a novel focus on differential coupling between psychopathology dimensions as a function of IQ.

Method

A total of 70 dimensional measures of psychopathology, plus IQ and demographic data, were collated for 2,752 children and adolescents from the Healthy Brain Network dataset. We first examined univariate associations between IQ and psychopathology, and then characterized how the correlational architecture of psychopathology differs between groups at extremes of the IQ distribution.

Results

Associations with IQ vary in magnitude between different domains of psychopathology: IQ shows the strongest negative correlations with attentional and social impairments, but is largely unrelated to affective symptoms and psychopathy. Lower IQ is associated with stronger coupling between internalizing problems and aggression, repetitive behaviors, and hyperactivity/inattentiveness.

Conclusion

Our analyses reveal that variation in general cognitive ability is associated not only with significant and selective shifts in severity of psychopathology, but also in the coupling between different dimensions of psychopathology. These findings have relevance for the clinical assessment of mental health in populations with varying IQ, and may also inform ongoing efforts to improve the measurement of psychopathology and to understand how relationships between cognition and behavior are reflected in brain organization.

Diversity & Inclusion Statement

We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure sex balance in the selection of non-human subjects. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. One or more of the authors of this paper received support from a program designed to increase minority representation in science. We actively worked to promote sex and gender balance in our author group. We actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our author group. While citing references scientifically relevant for this work, we also actively worked to promote sex and gender balance in our reference list. The author list of this paper includes contributors from the location and/or community where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented sexual and/or gender groups in science.

中文翻译：

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智商调节儿童和青少年精神病理学不同维度之间的耦合

客观的

认知能力与精神病理学之间的相关性已得到充分认可，但之前的研究因关注智力障碍者、单一诊断的精神病人群或少数精神病理学指标而受到限制。在这里，我们量化了不同求医人群中全面智商与精神病理学多个维度之间的关系，并特别关注作为智商函数的精神病理学维度之间的差异耦合。

方法

从健康大脑网络数据集中整理了 2,752 名儿童和青少年的总共 70 个心理病理学维度测量值，以及智商和人口统计数据。我们首先检查了智商和精神病理学之间的单变量关联，然后描述了精神病理学的相关结构在智商分布的极端群体之间有何不同。

结果

与智商的关联在精神病理学的不同领域之间的大小不同：智商显示出与注意力和社交障碍最强的负相关，但在很大程度上与情感症状和精神病无关。较低的智商与内化问题和攻击性、重复行为以及多动/注意力不集中之间的更强耦合有关。

结论

我们的分析表明，一般认知能力的变化不仅与精神病理学严重程度的显着和选择性变化有关，而且与精神病理学不同维度之间的耦合有关。这些发现与不同智商人群的心理健康临床评估相关，也可能为改进精神病理学测量和了解认知与行为之间的关系如何反映在大脑组织中的持续努力提供信息。

多元化和包容性声明

我们努力确保在招募人类参与者时实现性别平衡。我们努力确保选择非人类受试者时的性别平衡。本文的一位或多位作者自称是一个或多个历史上在科学界代表性不足的种族和/或族裔群体的成员。本文的一位或多位作者得到了一项旨在增加少数族裔在科学领域的代表性的计划的支持。我们积极致力于促进作者群体中的性和性别平衡。我们积极努力促进将历史上代表性不足的种族和/或族裔群体纳入我们的作者群体。在引用与这项工作科学相关的参考文献的同时，我们还积极努力促进参考文献列表中的性和性别平衡。本文的作者名单包括来自开展研究的地点和/或社区的贡献者，他们参与了数据收集、设计、分析和/或对工作的解释。本文的一位或多位作者自称是科学界一个或多个历史上未被充分代表的性和/或性别群体的成员。