• Development in higher organisms requires proper gene silencing, partially achieved through trimethylation of lysine 27 on histone H3 (H3K27me3). However, how the normal distribution of this modification is established and maintained and how it affects gene expression remains unclear, especially in fungi. Polycomb repressive complex 2 (PRC2) catalyzes H3K27me3 to assemble transcriptionally repressed facultative heterochromatin and is crucial in animals, plants, and fungi.

中文翻译：

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额外的 PRC2 亚基和 Sin3 组蛋白去乙酰化酶复合物是稻瘟病菌 H3K27me3 占有率的正态分布和转录沉默所必需的

• 高等生物的发育需要适当的基因沉默，部分通过组蛋白H3 (H3K27me3) 上赖氨酸27 的三甲基化来实现。然而，如何建立和维持这种修饰的正态分布以及它如何影响基因表达仍不清楚，尤其是在真菌中。Polycomb 抑制复合物 2 (PRC2) 催化 H3K27me3 组装转录抑制的兼性异染色质，在动物、植物和真菌中至关重要。