To explore the distribution of several bone metabolic indicators in type 2 diabetes patients (T2DM) with and without non-alcoholic fatty liver disease (NAFLD) and to preliminarily evaluate the relationship of bone metabolism with NAFLD in patients with T2DM. The hospitalized patients with T2DM were divided into the group of T2DM complicated with NAFLD and the group of T2DM alone according to the results of ultrasonic diagnosis. The general information and laboratory test data such as bone metabolism indexes of these patients were collected and the differences of the indexes between the 2 groups were compared. Furthermore, the independent influencing factors of NAFLD in patients with T2DM were analyzed. A total of 186 patients were included in the study. Compared with patients with T2DM only, patients with T2DM combined with NAFLD were characterized with younger age (p < 0.001), higher BMI (p = 0.016), ALT (p = 0.001), TG (p = 0.005), HOMA-IR (p = 0.005), and lower HDL-C (p = 0.031). Significant discrepancy of age (OR 1.052, p = 0.001), ALT (OR 0.964, p = 0.047), HOMA-IR (OR 0.801, p = 0.005), and T-PINP (OR 1.022, p = 0.008) was found using multivariate logistic regression model. Significant discrepancy of T-PINP was found in T2DM patients with and without NAFLD. Further studies are needed to explore whether T-PINP could be used as a predictor of fatty liver disease, osteoporosis, and other related complications in patients with T2DM.

探讨合并和不合并非酒精性脂肪性肝病（NAFLD）的2型糖尿病患者（T2DM）几种骨代谢指标的分布，并初步评价其与骨代谢的关系患有 NAFLD 的 T2DM 患者。根据超声诊断结果将住院的T2DM患者分为T2DM合并NAFLD组和单纯T2DM组。收集这些患者的一般资料和骨代谢指标等实验室检查资料，比较2组指标的差异。进一步分析了T2DM患者发生NAFLD的独立影响因素。共有 186 名患者被纳入研究。与单纯 T2DM 患者相比，T2DM 合并 NAFLD 患者具有年龄更小（ p< 0.001）、BMI（p= 0.016）、ALT（p= 0.001）、TG（p= 0.005）、HOMA-IR（p = 0.005)，以及较低的 HDL-C ( p = 0.031)。使用以下方法发现年龄 (OR 1.052, p = 0.001)、ALT (OR 0.964, p = 0.047)、HOMA-IR (OR 0.801, p = 0.005) 和 T-PINP (OR 1.022, p = 0.008) 存在显着差异多元逻辑回归模型。在伴有和不伴有 NAFLD 的 T2DM 患者中发现 T-PINP 存在显着差异。需要进一步的研究来探索 T-PINP 是否可以用作 T2DM 患者脂肪肝、骨质疏松症和其他相关并发症的预测因子。